منابع مشابه
Viruses as hijackers of PML nuclear bodies.
Promyelocytic leukemia nuclear bodies (PML-NBs) are discrete interchromosomal macromolecular structures. The integrity of this dynamic nuclear subcompartment critically depends on the presence of the name-giving PML protein. Among the permanent or transient residents of PML-NBs are various regulatory proteins, including Sp100, CBP, pRb, HIPK2, RAD51 and p53. PML-NBs are frequently targeted by v...
متن کاملPML nuclear bodies.
PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have fascinated cell biologists because of their beauty and their tight association with cellular disorders. The identification of PML, a gene involved in an oncogenic chromosomal translocation, as the key organizer of these d...
متن کاملAssembling PML nuclear bodies as functional subcompartments for telomere lengthening
The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape senescence and apoptosis in the absence of active telomerase. A characteristic feature of this pathway is the assembly of ALT-associated PML nuclear bodies (APBs) at telomeres. We dissected the role of APBs in a human ALT cell line by RNA interference with an automated 3D fluorescence microscopy platform in c...
متن کاملPML nuclear bodies in the pathogenesis of
1. Abstract 2. Introduction 2.1. The PML gene 2.2. PML nuclear bodies (PML-NBs) 3. PML-NB disruption and acute promyelocytic leukemia (APL) 3.1. t (15;17) associated APL and PML-NB disruption 3.2. Alternative APL Fusions 3.3. Homodimerization of the APL fusion proteins 3.4. Is forced dimerization of RARA and transcriptional repression sufficient for leukemogenesis? 4. Evidence supporting PML-NB...
متن کاملAcute promyelocytic leukemia, arsenic, and PML bodies
Acute promyelocytic leukemia (APL) is driven by a chromosomal translocation whose product, the PML/retinoic acid (RA) receptor α (RARA) fusion protein, affects both nuclear receptor signaling and PML body assembly. Dissection of APL pathogenesis has led to the rediscovery of PML bodies and revealed their role in cell senescence, disease pathogenesis, and responsiveness to treatment. APL is rema...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2021
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.11.1973